Association between ABCB1 C3435T Polymorphism and Statins Effectiveness Among Chinese Population: A Meta-Analysis / 中国药学杂志

ABSTRACT

OBJECTIVE: To evaluate the association between ABCB1 C3435T polymorphism and statins effectiveness among Chinese population. METHODS: Databases including PubMed, Web of Scien, Cochrance Library, CNKI, WanFang Data and VIP were searched to retrieve the relevant references from the start to August 2016. A quality assessment was performed using the Methodological Index for Non-Randomized Studies(MINORS)criteria. Meta-analysis, sensitivity analysis(RevMan 5.3)were all done. RESULTS: A total of 4 studies were included for final Meta-analysis, involving 630 participants. The efficacy was evaluated by the change in TC (total cholesterol), TG(triglyceride), HDL-C(high density lipoprotein-cholesterol), and LDL-C(low density lipoprotein-cholesterol) after statin treatment. The pooled MDs were assessed for the dominant genetic model (CT+TT vs.CC), recessive genetic model (TT vs. CC+CT) and homozygote comparison (TT vs. CC).Overall, there was no statistically significant association for the four genetic models of statins effectiveness. CONCLUSION: There is no association between ABCB1 C3435T polymorphism and statins effectiveness among Chinese population.