Association between 5-HT2A Receptor Gene Promoter -1438A/G Polymorphism and Bipolar Disorder in a Korean Population / 신경정신의학

ABSTRACT

OBJECTIVES: This study was designed to investigate the association between 5-HT 2A receptor gene promoter -1438A/G polymorphism and bipolar disorder in a Korean population. METHOD: 5-HT2A receptor gene promoter -1438A/G polymorphism were typed with Polymerase Chain Reaction in 120 patients with bipolar disorder and 120 normal controls. RESULT: The distributions of the genotype in the bipolar disorder with A/A, A/G, G/G were 14 (12%), 66(55%), 40(33%), and in the controls were 30(25%), 59(49%), and 31(26%). The allele frequencies of the bipolar disorders with A and G were 94(39.2%), 146(60.8%), and in the controls were 119(49.6), and 121(50.4), respectively. There were significant differences in genotype distributions and allele frequencies of -1438A/G between patients with bipolar disorder and normal controls. CONCLUSION: These results suggest that 5-HT2A receptor gene promoter -1438A/G polymorphism may be related to the development of bipolar disorder in a Korean population.