Population pharmacokinetic study of biapenem in critical patients / 中国药学杂志
Chinese Pharmaceutical Journal
; (24): 478-482, 2016.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-859175
Responsible library:
WPRO
ABSTRACT
OBJECTIVE:
To research population pharmacokinetics of biapenem in critical patients after repeated dosing.METHODS:
Blood samples were collected according to the different time points after intravenous administration of 300 mg for many times in the group of critical patients. High-performance liquid chromatography (HPLC) was used to determine the drug concentration in plasma.And pharmacokinetic parameters was caculated.RESULTS:
The main pharmacokinetic parameters for critical patients were as follows ρmax was (6.66±2.93)mg·L-1, Tmax was (0.51±0.04) h, AUC0-∞ was (18.98±16.95) mg·h·L-1, T1/2 was (2.06±1.93) h, Cl was (20.9±17.4) L·h-1, Vd was (46.43±3.5) L.CONCLUSION:
The pharmacokinetic parameters of biapenem in critical patients with a significant difference was found in healthy people. So need according to pharmacokinetic characteristics of patients to develop personalized anti-infection plan.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
2016
Document type:
Article