Identification of a metal ion-induced degradation impurity in huperzine A injection / 中国药学杂志
Chinese Pharmaceutical Journal
; (24): 634-638, 2015.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-859408
Responsible library:
WPRO
ABSTRACT
OBJECTIVE:
To identify the structure of an impurity of huperzine A injection.METHODS:
HPLC-QTOF-MS was adopted to analyze the structure of the impurity, which was further isolated and prepared by prep-HPLC and the structure was established on the basis of spectroscopic data.RESULTS:
The impurity was elucidated as (111E)-7,8-dichloro-5-amino-11-ethylidene-7-methyl-5,8,9,10-tetrahydro-5,9-methenecyclooctatriene [b] pyridin-2(1H)-one.CONCLUSION:
The impurity was deduced as a metal ion-induced degradation product. This investigation provides reference for the improvement of quality control and process optimization of huperzine A injection.
Full text:
Available
Database:
WPRIM (Western Pacific)
Type of study:
Diagnostic study
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
2015
Document type:
Article