Effects of betaine, taurine, lycium barbarum polysaccharides in lycium barbarum L. on the pharmacokinetics of β-carotene in beagle dogs / 中国药学杂志

ABSTRACT

OBJECTIVE: To study the effects of betaine, taurine, lycium barbarum polysaccharides (LBP) in Lycium barbarum L. on the pharmacokinetics of β-carotenes(β-C) in beagle dogs. METHODS: Six Beagle dogs divided into two groups randomly, were given β-carotenes or β-carotenes combined with betaine, taurine or LBP, respectively. The concentrations of β-caro-tenes, retinol and retinol palmitate in dog plasma at different time points were determined by HPLC method. The main pharmacokinetic parameters were processed by the software DAS2.0.1. RESULTS: Compared with β-carotenes group, the t1/2 of β-carotenes was prolonged (P 0.05). CONCLUSION: Other ingredients in Lycium barbarum L. could influence the pharmacokinetic process of in Beagle dogs. The functions of nourishing liver and improving eyesight by Lycium barbarum L. did not result from a single component, but from its multi-ingredients.