Sustained release solid dispersion of tripterine carried by modified nano-CaCO3 / 中国药学杂志

ABSTRACT

OBJECTIVE: To prepare hydrophobic nano-CaCO3 by nano-CaCO3 and stearic acid. And to prepare tripterine solid dispersion using the new material as a carrier by solvent method. METHODS: The structure of modified nano-CaCO3 was characterized by TEM, DSC, XRD and FTIR. Meanwhile the solid dispersions were characterized by SEM, DSC, XRD and FTIR, and the in vitro dissolution test of tripterine was performed. RESULTS: When the ratio of drug to modified nano-CaCO3 was 1:4, tripterine could be dispersed amorphously in the carrier. And the accumulative drug-release percentage in vitro at 0.5 h was 7.05%. With the time increasing, the accumulative drug-release percentage also increased to 90.03% at 12 h. Moreover, tripterine solid dispersion had a better sustained release effect. CONCLUSION The nano-CaCO3 modified by stearic acid can be used as controlled-release carrier for tripterine.