Rapid determination of chromium in medicinal capsules by inductively coupled plasma mass spectrometry / 中国药学杂志

ABSTRACT

OBJECTIVE: To establish a method for rapid determination of chromium (Cr) in medicinal capsules by inductively coupled plasma mass spectrometry (ICP-MS). METHODS: With 45Sc as internal st andard element, Cr in medicinal capsules was directly analyzed by ICP-MS after microwave digestion, and this method was compared with the ChP 2010 method (GFAAS method). RESULTS: The correlative coefficient (r) for Cr was 1.000 O, the limit of detection was 0.079 μg · L-1, the precision and stability were satisfactory with all RSDs less than 4%, the spiked recoveries of high, middle and low level ranged from 96.77% to 101.5%, the determined values of tea reference material (GBW 07605) and tomato leaves reference material (SRM 1573a) met well with those certified. Method comparison indicated good accordance between this method and the ChP method. CONCLUSION: This method is simple and accurate, and could be used as an alternative method to the ChP method.