Determination of correction factors of pantoprazole sodium impurity / 中国药学杂志
Chinese Pharmaceutical Journal
; (24): 2029-2031, 2012.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-860535
Responsible library:
WPRO
ABSTRACT
OBJECTIVE:
To select appropriate liquid chromatography conditions to determine the correction factors for the related compounds A, B, C, D + F and E of pantoprazole thus to establish the determination method of the related substances.METHODS:
The separation was achieved on a C18 column(4. 6 mm × 250 mm, 5 μm) utilizing a mobile phase of acetonitrile and 0.01 mol · mL-1 dipo-tassium hydrogen phosphate(0 min, 8020; 40 min, 4060; 45 min, 2080)at a flow rate of 1.0 mL · min-1. The column temperature was set at 35°C. The compounds were monitored at 288 nm.RESULTS:
Pantoprazole sodium and its impurities were well separated by the method. The correction factors of pantoprazole related compounds A, B, C, D + F and E were 0.94, 0.93, 0.67, 0.96 and 0.99.CONCLUSION:
The method can be used for the quality control of pantoprazole sodium and its related substances in the preparations.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmaceutical Journal
Year:
2012
Document type:
Article