Chemical constituents of Medicago polymorpha / 中国药学杂志

ABSTRACT

OBJECTIVE: To study the chemical constituents of the aerial parts of Medicago polymorpha Linn. METHODS: Compounds were separated by column chromatography with silica gel and Sephadex LH - 20. Their structures were elucidated on the basis of physiochemical and spectral analyses. RESULTS: Fourteen compounds were obtained and elucidated as apigenin(1), apigenin-7-O-β-D-glucopyranoside (2), apigenin-7-O-β-D-glucuronopyranoside methyl ester (3), apigenin-7-P-β-D-glucuronopyranoside butyl ester(4), luteolin(5), isoformononetin(6), isoliquiritigenin(7), echinocystic acid-3-O-[-O-α-L-rhamnosyl-(1 → 2) - α-L-arabinoside] (8), coumestrol(9), adenine(10), xanthine(11), n-nonyl triacontanol(12), daucosterol(13), and β-sitosterol (14). CONCLUSION: These compounds were isolated from Medicago polymorpha for the first time. Compounds 3, 4, 6, 8, 10, 11 and 12 were isolated from the Medicago genus for the first time. Copyright 2012 by the Chinese Pharmaceutical Association.