Dual-phase 18F-FDG PET/CT in diagnosis of different types of extrahepatic cholangiocarcinomas / 中国医学影像技术

ABSTRACT

Objective: To explore the value of dual-phase 18F-FDG PET/CT in diagnosis of different types of extrahepatic cholangiocarcinomas (EHCC). Methods: Data of 71 patients with suspected EHCC who underwent preoperative dual-phase 18F-FDG PET/CT scanning were retrospectively analyzed. According to 18F-FDG PET/CT imaging and pathological results, the patients were divided into mass-forming EHCC group (n=20), non-mass-forming EHCC group (n=34) and benign diseases group (n=17). The diagnostic efficiency of dual-phase 18F-FDG PET/CT was calculated. The maximal standardized uptake value (SUVmax), tumor SUVmax/liver SUVmean ratio (T/L) and retention index (RI) of dual-phase 18F-FDG PET/CT were compared in those with positive findings among 3 groups. ROC curves were used, and the AUC were compared. Results: The diagnostic sensitivity of early and delayed 18F-FDG PET/CT for non-mass-forming EHCC was 70.59% (24/34) and 73.53% (25/34), respectively. In all patients with positive findings, SUVmax and T/L of mass-forming EHCC were higher than those of benign diseases (all P0.05). The best cut-off of RISUV was 6.0%. The diagnostic sensitivity and accuracy of dual-phase 18F-FDG PET/CT for non-mass-forming EHCC can be improved with the combination of early phase SUVmax>3.1 and RISUV>6.0%. Conclusion: Dual-phase 18F-FDG PET/CT might be helpful to improving diagnostic accuracy of non-mass-forming EHCC.