Advances in Research on Nrf2 Signaling Pathway in Inflammatory Bowel Disease / 胃肠病学

ABSTRACT

Nuclear factor-erythroid 2 related factor-2 (Nrf2) is the main protective molecule of cells against external pressure with an anti-oxidative stress and anti-inflammatory effect. Inflammatory bowel disease (IBD) is a chronic non-specific intestinal inflammatory disease with a high risk of developing intestinal fibrosis and colorectal cancer. Many studies have confirmed that Nrf2 and its downstream pathway play important roles in IBD intestinal fibrosis and carcinogenesis. Therapeutic drugs targeting Nrf2 signaling pathway are being widely studied. This article reviewed the advances in research on Nrf2 signaling pathway in IBD.