Role of TNF-α in Development and Progression of Inflammatory Bowel Disease / 胃肠病学

ABSTRACT

Inflammatory bowel disease (IBD) is a chronic and recurrent inflammation of gastrointestinal tract caused by disorder of immune system. It includes Crohn's disease (CD) and ulcerative colitis (UC). Many factors such as environment and dysbiosis of gut microbiota can lead to IBD. TNF-α is generally considered as playing an important role in the development and progression of IBD. This article reviewed the role of TNF-α in the pathogenesis of IBD.