Progress of extraintestinal manifestations of inflammatory bowel disease in children / 国际儿科学杂志

ABSTRACT

Inflammatory bowel disease(IBD)is a group of chronic intestinal inflammatory diseases with unknown etiology and pathogenesis.It usually presents chronic diarrhea, mucous bloody stool, recurrent abdominal pain and other non-specific intestinal manifestations, and it is also accompanied by recurrent fever, growth delay.More studies show that IBD not only affects the intestinal function, but also involves the external organs of the body.The most involved organs include the mouth, joints, skin and eyes.Its pathogenesis is related to genetic susceptibility, immune system disorder and the influence of intestinal microbiota.In addition, the extraintestinal manifestations of inflammatory bowel disease can occur several years before and after diagnosis, which can easily cause delay in diagnosis.Therefore, clinicians should be aware of the various manifestations of inflammatory bowel disease and develop a treatment plan.This review will state the recent progress of extraintestinal manifestations of inflammatory bowel disease in children.