Clinical study of Tiaozhi granule combined with rosuvastatin calcium tablets in the treatment of phlegm and blood stasis syndrome of hyperlipidemia

Gaoyang XU; Jingwei CHEN; Wei XU

ABSTRACT

Objective:

To observe the effect of Tiaozhi granule combined with rosuvastatin calcium tablets in the treatment of phlegm and blood stasis syndrome of hyperlipidemia.

Methods:

A total of 108 patients with hyperlipidemia who met the inclusion criteria in our hospital from March 2016 to December 2017 were recruited and randomly divided into 2 groups with 54 patients in each group. The control group took rosuvastatin calcium tablets orally, and the observation group tookTiaozhi granule on the basis of the control group. Both groups received continuous treatment for 3 months. TCM symptoms were scored, and serum TG, TC, LDL-C and HDL-C levels were detected by automatic biochemical analyzer. The Homocysteine (Hcy) levels were detected by chemiluminescence, the Intercellular adhesion molecule-1 (ICAM-1) levels were detected by ELISA, the endothelin (ET) levels were determined by radio-immunoassay, and the NO levels were determined by nitrate reductase. The Intima-media thickness (IMT) of carotid artery was determined by color doppler ultrasound imaging, and the clinical efficacy was evaluated.

Results:

The total effective rate was 92.6% (50/54) in the observation group and 77.8% (42/54) in the control group, and the difference between the two groups was statistically significant ( χ2=4.696, P=0.030). After the treatment, the scores of vertigo, chest tightness, sputum and limb anesthesia in the observation group were significantly lower than those in the control group ( t value were 3.630, 4.035, 3.184, 5.372, respectively, all Ps<0.01). Serum levels of TG, TC and LDL-C in the observation group were significantly lower than those of the control group ( t value were 6.073, 3.159, 5.020, respectively, all Ps<0.01), and HDL-C levels were significantly higher than those of the control group ( t=7.120, P<0.05). After the treatment, IMT (1.64 ± 0.17 mm vs. 2.35 ± 0.08 mm, t=-15.928) in the observation group was significantly lower than that of the control group ( P<0.01). After the treatment, the serum levels of Hcy, ICAM-1 and ET in the observation group were significantly lower than that of the control group ( t value were 5.346, 14.281, 19.028, respectively, all Ps<0.01). The NO level was significantly higher than that of the control group ( t=13.035, P<0.01).

Conclusions:

Tiaozhi granule combined with rosuvastatin calcium tablets can improve the disorder of lipid metabolism in patients with hyperlipidemia, reduce IMT and improve clinical efficacy.