Comparison of effects of metaraminol and norepinephrine on elderly patients with septic shock / 中华急诊医学杂志
Chinese Journal of Emergency Medicine
; (12): 547-550, 2020.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-863790
Responsible library:
WPRO
ABSTRACT
Objective:
To compare the effect of metaraminol and norepinephrine (NA) on elderly patients with septic shock.Methods:
In this multicenter prospective cohort study elderly patients with septic shock were divided into the metaraminol group ( n=100) and NA group ( n=100). The 28-day survival and average hospital stay, the hemodynamics and renal function of the patients were observed.Results:
The average hospital stay in the metaraminol group was lower than that in the NA group ( P < 0.05). Blood pressure, heart rate, arterial lactate, B-type natriuretic peptide, left ventricular ejection fraction and 28-day survival had no significant differences between the two groups (all P > 0.05). The average urine output at day 3 and 7 after the administration of vasopressor in the metaraminol group were higher than those in the NA group (all P< 0.05), blood urea nitrogen at day 3, 7 and 14 after the administration of vasopressor in the metaraminol group were lower than those in the NA group (all P < 0.05), and the creatinine at day 3, 7 and 14 after the administration of vasopressor and the rate of renal replacement therapy in the metaraminol group were lower than those in the NA group (all P < 0.05).Conclusions:
Metaraminol has similar effect to norepinephrine in improving 28-day survival and hemodynamics of elderly patients with septic shock, but is superior to norepinephrine in reducing the average hospital stay and protecting renal function.
Full text:
Available
Database:
WPRIM (Western Pacific)
Type of study:
Controlled clinical trial
/
Observational study
Language:
Chinese
Journal:
Chinese Journal of Emergency Medicine
Year:
2020
Document type:
Article