Research progress of mild hypothermia combined with neuroprotective agents in the treatment of neonatal hypoxic-ischemic encephalopathy / 中国小儿急救医学

ABSTRACT

Neonatal hypoxic-ischemic encephalopathy(HIE) is one of the critical diseases in neonatal ward, which can lead to neonatal death or serious neurological sequelae.Mild hypothermia treatment is currently accepted.Although it could reduce the mortality and the risk of neurological sequelae of neonates with moderate and severe HIE to a certain extent, there were still some children who died or left neurological dysfunction.Neuroprotective agents play an important role in anti-excitotoxicity, anti-oxidation, anti-inflammatory and anti-apoptosis.This review provided the research progress of the combination of mild hypothermia and neuroprotective agents in the treatment of neonatal HIE.