Review and analysis on knockout mouse models with cataract / 中华实验眼科杂志
Chinese Journal of Experimental Ophthalmology
; (12): 710-714, 2020.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-865328
Responsible library:
WPRO
ABSTRACT
Cataract is the leading cause of blindness worldwide, which is a generally clinical and genetic heterogeneity eye disease.To date, more than 50 genes have been reported to be associated with congenital cataract.While for mouse, parts of human cataract related genes knockout mouse can also resulted cataract.As we know, the model of cataract related gene knockout mice can help us to understand the phenotype, pathogenesis, progress and prognosis of human cataract and it can also help to find unknow genes that not reported in human cataract yet.In this review, knockout mouse models with cataract are summarized, which can help to facilitate identification of cataract genes and clarification of the mechanisms of cataractgenisis.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Experimental Ophthalmology
Year:
2020
Document type:
Article