Prevention and treatment strategies for sarcopenic obesity in the elderly / 中华老年医学杂志

ABSTRACT

Sarcopenic obesity(SO)has been a hot issue in the field of geriatrics.SO is associated with major adverse health consequences such as falls, disability, fractures, cardiometabolic diseases, cancer and death.The pathogenesis of SO is still unclear, mainly involving age-related changes in body composition, chronic low-grade inflammation, insulin resistance and sex-specific hormonal changes.Lifestyle interventions, including rational nutrition, physical activity, and especially aerobic exercise and resistance training, are the cornerstones of SO treatment.Emerging therapies include testosterone supplements, selective androgen receptor modulators, myostatin inhibitors, whole body vibration therapy, vitamin K and mesenchymal stem cell therapy.There is an urgent need for researchers and clinicians to have an in-depth understanding of the pathogenesis of SO and carry out effective prevention and treatment.