Application of skin biopsy in neurological disorders / 中华神经科杂志
Chinese Journal of Neurology
; (12): 839-844, 2020.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-870890
Responsible library:
WPRO
ABSTRACT
The skin is the largest organ comprised of three main layers epidermis, dermis and subcutaneous tissue. Characteristic microscopic and ultrastructural alterations are present in certain skin structures, such as nerve fibers, blood vessels and sweat glands, not only in vasculitis, but in several other metabolic neurologic diseases. In recent years, advances in immunohistochemistry and electron microscopy have made these dermatopathological changes identifiable and clear-cut. It was then recognized that such pathological feature could be present in many tissues in addition to those nerve systems clinically affected. Skin biopsy has become a recognized diagnostic procedure for peripheral neuropathy and central nervous system diseases. This article reviews the dermatopathology in neurological disorders under light and electron microscope to promote application of skin biopsy in clinical diagnosis for neurologist.
Full text:
Available
Database:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Journal of Neurology
Year:
2020
Document type:
Article