Investigation of Positive Streptococcus pneumoniae Urinary Antigen Test Results in a Korean University Hospital / 대한임상미생물학회지
Korean Journal of Clinical Microbiology
; : 14-18, 2010.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-87117
Responsible library:
WPRO
ABSTRACT
BACKGROUND:
The Streptococcus pneumoniae urinary antigen test (SPUAT) (Binax Now, USA) was developed for detecting polysaccharide C in urine samples for rapid diagnosis of pneumococcal pneumonia, the most common cause of community-acquired pneumonia (CAP). To validate positive results of these tests, we retrospectively investigated all positive results obtained from the emergency room of a Korean university hospital among patients with suspected CAP.METHODS:
One hundred twenty-three positive SPUAT results were abstracted and analyzed from the authors' laboratory information system among the SPUAT results performed from 1,143 pneumonic patients admitted from the emergency room of a university hospital between 2007 and 2008. Medical records, including conventional microbiologic analysis results, were reviewed in detail for all positive test results.RESULTS:
Among 123 patients with the positive SPUAT results, 24 patients were excluded due to hospitalization history during the preceding month. Nine of 99 patients (9.1%) with suspected CAP had confirmed pneumococcal pneumonia upon conventional sputum or blood culture. Thirty-five positive results (35.4%) showed other microorganisms upon conventional methods, which might be due to possible cross-reactivity. Among those, 23 positive results were considered bacterial pneumonic agents, and 12 positive results were regarded as urinary tract infection strains or contaminating agents. Fifty-five positive SPUAT results (55.6%) showed negative conventional microbiologic growth, and some positive SPUAT results might be caused by true pneumococcal infection although without cultural evidence.CONCLUSION:
Our retrospective study demonstrated that a positive SPUAT result typically does not agree well with conventional culture methods, suggesting that the value of a positive SPUAT result in etiology determination may be limited under practical conditions in a university hospital.
Full text:
Available
Health context:
Sustainable Health Agenda for the Americas
Health problem:
Goal 6: Information systems for health
Database:
WPRIM (Western Pacific)
Main subject:
Pneumococcal Infections
/
Pneumonia
/
Pneumonia, Pneumococcal
/
Sputum
/
Streptococcus
/
Streptococcus pneumoniae
/
Urinary Tract Infections
/
Medical Records
/
Retrospective Studies
/
Clinical Laboratory Information Systems
Type of study:
Observational study
Limits:
Humans
Language:
English
Journal:
Korean Journal of Clinical Microbiology
Year:
2010
Document type:
Article