Ｒeview on the association of CAG short tandem repeats of androgen receptor gene with tumorigenesis and prognosis / 中华疾病控制杂志

ABSTRACT

@#Abnormal expression of androgen receptor ( AＲ) and AＲ-mediated signaling pathways are closely related to the occurrence，outcome，and prognosis of various human disease，and to some ex- tent，AＲ lead to gender differences in these diseases． However，the specific mechanism is still unclear． CAG short tandem repeat ( STＲ) sequence in exon 1 of AＲ gene negatively correlates with the transcriptional regulation activity，affects the synthesis and biological function of the target proteins，and plays an important role in the development and prognosis of various tumors，such as prostate cancer，breast cancer，bladder cancer，liver cancer，and endometrial cancer． In this review，we summarized the current studies on the association between AＲ gene CAG STＲ and the common tumors，in order to provide clues for further exploring the mechanism of AＲ-related tumors with high incidence and gender differences，and screening populations with high risk for the corresponding tumors．