Study on the antifungal activity of phenazine derivatives / 药学实践杂志
Journal of Pharmaceutical Practice
; (6): 249-254, 2021.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-876858
Responsible library:
WPRO
ABSTRACT
Objective To study the antifungal activity of phenazines derivatives. Methods The anti-fungal activity of phenazine compounds was evaluated initially with micro-liquid dilution. No significant antifungal activity against Candida albicans was found. Then, with the combination of phenazine compounds and fluconazole, the anti-fungal activity against fluconazole-resistant C. albicans was detected. Results The phenazine-17 had significant antifungal activity when combined with fluconazole through the inhibition of hyphae formation. Conclusion This study provides a new idea for the development of antifungal drugs and the solution of antifungal drug resistance.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Pharmaceutical Practice
Year:
2021
Document type:
Article