Ferroptosis in respiratory diseases / 生理学报
Acta Physiologica Sinica
; (6): 575-585, 2020.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-878203
Responsible library:
WPRO
ABSTRACT
Ferroptosis is a novel form of regulated cell death which is dependent on iron and reactive oxygen species (ROS) and associated with the accumulation of lipid peroxides. It is obviously different from other cell death types in terms of morphology, biochemistry, genetics, etc. Also, it is related to the production of iron catalyzed lipid peroxides which is triggered by non-enzymatic or enzymatic reactions. Ferroptosis has been proved to be involved in hematological diseases, cardio-cerebrovascular diseases, liver and kidney diseases. This paper will review the definition, mechanism, inducers of ferroptosis, as well as the function of ferroptosis in respiratory system. We expect to present a new concept for respiratory research and suggest potential targets for clinical prevention and treatment of respiratory diseases.
Full text:
Available
Health context:
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Other Respiratory Diseases
Database:
WPRIM (Western Pacific)
Main subject:
Respiration Disorders
/
Cell Death
/
Reactive Oxygen Species
/
Ferroptosis
/
Iron
Limits:
Humans
Language:
Chinese
Journal:
Acta Physiologica Sinica
Year:
2020
Document type:
Article