Clinical significance of PD / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 1149-1154, 2020.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-880579
Responsible library:
WPRO
ABSTRACT
OBJECTIVES@#To explore the expression of programmed death ligand-1 (PD-L1) as well as the correlation between the expression and the clinicopathological features or prognosis in non-small cell lung cancer (NSCLC).@*METHODS@#The expression of PD-L1 protein in 254 cases of surgically resected lung adenocarcinoma (L-ADC), 228 cases of surgically resected lung squamous cell cancer (L-SCC), and 99 cases of non-cancerous control lung tissues was detected with immunohistochemical SP method. The correlation between the PD-L1 expression and clinicopathological features was analyzed. Kaplan-Meier univariate and Cox multivariate regression analyses were performed to assess the prognosis of patients with L-ADC and L-SCC, respectively.@*RESULTS@#Positive percentage of PD-L1 protein expression was higher in the tissues of L-ADC and L-SCC than that in the non-cancerous control lung tissues respectively (both @*CONCLUSIONS@#The positive percentage of PD-L1 protein expression is higher in the L-SCC patients than that in the L-ADC patients. Positive expression of PD-L1 protein can be served as an independent prognostic factor of poor prognosis in the patients with L-ADC.
Full text:
Available
Health context:
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Other Respiratory Diseases
/
Trachea, Bronchus, Lung Cancers
Database:
WPRIM (Western Pacific)
Main subject:
Patients
/
Prognosis
/
Biomarkers, Tumor
/
Carcinoma, Non-Small-Cell Lung
/
B7-H1 Antigen
/
Adenocarcinoma of Lung
/
Lung Neoplasms
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Journal of Central South University(Medical Sciences)
Year:
2020
Document type:
Article