Effect of etomidate on the reuniens neuronal activity / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 39-46, 2021.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-880620
Responsible library:
WPRO
ABSTRACT
OBJECTIVES@#To explore the effect of etomidate on the neuronal activity of ventral thalamic reuniens nucleus and the underlying mechanisms.@*METHODS@#Whole-cell patch clamp method was used to explore the effect of etomidate on the activity of ventral thalamic reuniens neurons in the acute brain slices obtained from 4-5 weeks old C57BL/6J mice. The electrophysiological characteristics of ventral thalamic reuniens neurons were recorded in the current clamp mode, and then the effects of etomidate (0.5, 2.0, 8.0 μmol/L etomidate groups) and intralipid (intralipid group) on the discharge frequency and membrane potential of ventral thalamic reuniens neurons were recorded. During the experiment, the ventral thalamic reuniens neuron firing rates (RNFRs) were recorded as F@*RESULTS@#In the intralipid group, there was no significant difference among the F@*CONCLUSIONS@#Etomidate can inhibit the activity of ventral thalamic reuniens neurons in concentration-dependent manner, and which is reversible. Etomidate with sub-anesthetic concentration inhibits the activity of ventral thalamic reuniens neurons via targeting the GABA
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Receptors, GABA-A
/
Patch-Clamp Techniques
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Etomidate
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Mice, Inbred C57BL
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Neurons
Limits:
Animals
Language:
English
Journal:
Journal of Central South University(Medical Sciences)
Year:
2021
Document type:
Article