Establishment of a mouse model bearing orthotopic temozolomide-resistant glioma / 南方医科大学学报
Journal of Southern Medical University
; (12): 69-74, 2021.
Article
in Zh
| WPRIM
| ID: wpr-880829
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To establish a mouse model bearing orthotopic temozolomide (TMZ)-resistant glioma that mimics the development of drug resistance in gliomas @*METHODS@#Seventy-eight adult C57BL/6 mice were randomly divided into 6 groups (@*RESULTS@#The mouse models bearing TMZresistant glioma was successfully established. The cells from the high-dose induced group showed a significantly higher colony-forming rate than those from the high-dose control group (@*CONCLUSIONS@#Progressive increase of TMZ doses in mice bearing orthotopic gliomas can effectively induce TMZ resistance of the gliomas.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Brain Neoplasms
/
Drug Resistance, Neoplasm
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Antineoplastic Agents, Alkylating
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Cell Line, Tumor
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Disease Models, Animal
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Temozolomide
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Glioma
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Mice, Inbred C57BL
Limits:
Animals
Language:
Zh
Journal:
Journal of Southern Medical University
Year:
2021
Document type:
Article