Expression of Ki-67, Cyclin D1, P53, and P16 in patients with oral leukoplakia and leukoplakia cancerization with spicy diet in Chengdu / 华西口腔医学杂志
West China Journal of Stomatology
; (6): 434-440, 2021.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-887755
Responsible library:
WPRO
ABSTRACT
OBJECTIVES@#To investigate the expression of Ki-67, Cyclin D1, P53, and P16 in patients with oral leukoplakia (OLK) and OLK cancerization who have aspicy diet in Chengdu.@*METHODS@#Thirtypatients with OLK andspicy diet and 15 patients with OLK without spicy diet in Chengdu were divided into three groups hyperplastic OLK (OLK-), OLK with mild to moderate dysplasia (OLK+), and severe dysplastic OLK or oral squamous cell carcinoma (OSCC) transforming from OLK (OLK++/OSCC). The expression of Ki-67, Cyclin D1, P53, and P16 were detected by immunohistochemistry and statistically analyzed.@*RESULTS@#The expression of Ki-67 and P53 in patients with or without spicy diet in the OLK+and OLK++/OSCC groups were stronger than that of the OLK- group (@*CONCLUSIONS@#Spicy diet did not have an influence on the expression of Ki-67, Cyclin D1, P53, and P16 in patients with OLK and OSCC. The expression of Ki-67, Cyclin D1, and P53 increased with the development of OLK, whereas P16 showed opposite expression trend.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Leukoplakia, Oral
/
Mouth Neoplasms
/
Carcinoma, Squamous Cell
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Tumor Suppressor Protein p53
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Ki-67 Antigen
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Cyclin D1
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Diet
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Head and Neck Neoplasms
Limits:
Humans
Language:
English
Journal:
West China Journal of Stomatology
Year:
2021
Document type:
Article