Reconstitution of biosynthetic pathway for mushroom-derived cyathane diterpenes in yeast and generation of new "non-natural" analogues

Ke MA; Yuting ZHANG; Cui GUO; Yanlong YANG; Junjie HAN; Bo YU; Wenbing YIN; Hongwei LIU

Ke MA; Yuting ZHANG; Cui GUO; Yanlong YANG; Junjie HAN; Bo YU; Wenbing YIN; Hongwei LIU.

Acta Pharmaceutica Sinica B ; (6): 2945-2956, 2021.

Article in English | WPRIM (Western Pacific) | ID: wpr-888897

Responsible library: WPRO

ABSTRACT

ABSTRACT

Mushroom-derived cyathane-type diterpenes possess unusual chemical skeleton and diverse bioactivities. To efficiently supply bioactive cyathanes for deep studies and explore their structural diversity,

Biosynthesis; Cyathane-type diterpene; Heterologous expression; Non-enzymatic reaction

Fulltext

Add to My VHL

XML

Search on Google

Full text: Available Database: WPRIM (Western Pacific) Language: English Journal: Acta Pharmaceutica Sinica B Year: 2021 Document type: Article

Fulltext

Add to My VHL

XML

Search on Google

Full text: Available Database: WPRIM (Western Pacific) Language: English Journal: Acta Pharmaceutica Sinica B Year: 2021 Document type: Article