Parkinson's Disease with Fatigue: Clinical Characteristics and Potential Mechanisms Relevant to α-Synuclein Oligomer
Journal of Clinical Neurology
; : 172-180, 2016.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-88933
Responsible library:
WPRO
ABSTRACT
BACKGROUND AND PURPOSE:
The aim of this study was to identify the clinical characteristics and potential mechanisms relevant to pathological proteins in Parkinson's disease (PD) patients who experience fatigue.METHODS:
PD patients (n=102) were evaluated using a fatigue severity scale and scales for motor and nonmotor symptoms. The levels of three pathological proteins-α-synuclein oligomer, β-amyloid (Aβ)(1-42), and tau-were measured in 102 cerebrospinal fluid (CSF) samples from these PD patients. Linear regression analyses were performed between fatigue score and the CSF levels of the above-listed pathological proteins in PD patients.RESULTS:
The frequency of fatigue in the PD patients was 62.75%. The fatigue group had worse motor symptoms and anxiety, depression, and autonomic dysfunction. The CSF level of α-synuclein oligomer was higher and that of Aβ1-42 was lower in the fatigue group than in the non-fatigue group. In multiple linear regression analyses, fatigue severity was significantly and positively correlated with the α-synuclein oligomer level in the CSF of PD patients, after adjusting for confounders.CONCLUSIONS:
PD patients experience a high frequency of fatigue. PD patients with fatigue have worse motor and part nonmotor symptoms. Fatigue in PD patients is associated with an increased α-synuclein oligomer level in the CSF.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Anxiety
/
Parkinson Disease
/
Weights and Measures
/
Linear Models
/
Cerebrospinal Fluid
/
Depression
/
Fatigue
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Journal of Clinical Neurology
Year:
2016
Document type:
Article