Association between Antibiotic Consumption and Incidence of Clostridioides difficile Infection in a Hospital
Journal of Korean Medical Science
; : e407-2020.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-899713
Responsible library:
WPRO
ABSTRACT
Previous exposure to antimicrobials is a major risk factor for Clostridioides difficile infection (CDI). Antibiotic prescription and C. difficile toxin assay records of patients admitted to a tertiary hospital in Korea from 2009 to 2013 were collected to investigate the association between antibiotic consumption and CDI incidence. A Spearman's correlation analysis between CDI incidence (positive result of toxin assay/10,000 admissions) and antibiotic consumption (defined daily dose/1,000 patient-days) was performed on a monthly basis. Using the matched month approach, we found a significant correlation between CDI rate and moxifloxacin consumption (Spearman's r = 0.351, P < 0.001). Furthermore, using the onemonth delay approach, we found that the consumption of clindamycin (Spearman's r = 0.272, P = 0.037) and moxifloxacin (Spearman's r = 0.297, P = 0.022) was significantly correlated with CDI incidence. Extended-spectrum cephalosporins did not have any effect on CDI incidence.
Full text:
Available
Database:
WPRIM (Western Pacific)
Type of study:
Incidence study
/
Risk factors
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2020
Document type:
Article