Clinical outcomes of infection-related hospitalization in incident peritoneal dialysis patients
Kidney Research and Clinical Practice
; : 460-468, 2020.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-901508
Responsible library:
WPRO
ABSTRACT
Background@#Infection is the second leading cause of death in patients undergoing long-term dialysis. Peritoneal dialysis (PD) is associated with an increased risk of infection-related hospitalization (IRH) when compared with hemodialysis. In this study, we investigated the influence of IRH on clinical outcomes in incident PD patients. @*Methods@#In total, 583 incident PD patients were selected from the Clinical Research Center Registry for End-Stage Renal Disease, a nationwide multicenter prospective observational cohort study in Korea. Incident PD patients who had been hospitalized for infection-related diseases were defined as the IRH group. The primary outcome was all-cause mortality and the secondary outcome was technical failure. The median follow-up period was 29 months. @*Results@#Seventy-three PD patients (12.5%) were categorized in the IRH group. Multivariable logistic regression analysis showed that diabetes mellitus was a significant independent predictor for IRH (odds ratio, 2.43; 95% confidence interval [CI], 1.12 to 5.29; P = 0.007). The most common causes of IRH were peritonitis (63.0%) and respiratory tract infection (9.6%). Multivariable Cox proportional hazard model analysis showed that IRH was a significant independent risk factor for all-cause mortality (hazard ratio [HR], 2.51; 95% CI, 1.12 to 5.62; P = 0.026) and for the technical failure of PD (HR, 3.23; 95% CI, 1.90 to 5.51; P < 0.001). @*Conclusion@#Our data showed that after initiation of PD, IRH was significantly associated with higher risk of all-cause mortality and technical failure.
Full text:
Available
Health context:
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Other Malignant Neoplasms
Database:
WPRIM (Western Pacific)
Type of study:
Controlled clinical trial
/
Observational study
/
Prognostic study
/
Risk factors
Language:
English
Journal:
Kidney Research and Clinical Practice
Year:
2020
Document type:
Article