Advance of AMPK in Ischemic Stroke (review) / 中国康复理论与实践

ABSTRACT

AMP-activated protein kinase (AMPK) is an evolutionarily conserved serine/threonine kinase that plays a vital role in regulating the homeostasis of cellular energy metabolism. Under normal physiological conditions, AMPK can promote brain development and regulate neuronal polarization. In ischemic stroke, the upregulation of AMPK can reduce oxidative stress, inhibit neuroinflammation, regulate neuronal autophagy and apoptosis, improve mitochondrial function, inhibit glutamate excitotoxicity and promote neovascularization. AMPK can promote functional recovery in the treatment of ischemic stroke. The current treatment methods based on AMPK mainly include drug therapy, physical therapy and receptor targeted therapy. However, the evidence and mechanism of the application of targeting AMPK in the clinic are still not sufficient, and need further research.