Advance in Neurogranin for Cognitive Impairment Second to Central Nervous System Diseases (review) / 中国康复理论与实践
Chinese Journal of Rehabilitation Theory and Practice
; (12): 325-329, 2020.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-905784
Responsible library:
WPRO
ABSTRACT
Neurogranin (Ng), as a neuron-specific postsynaptic protein, is abundant in the cerebral cortex and hippocampus. Ng may alter the affinity with calmodulin through phosphorylation and redox, and participate in the calcium signal pathway through glutamate receptor, to regulate the information transfer and synaptic plasticity. Ng involves in the formation and encoding of memories in related brain regions and plays an important role in learning, memory and cognitive function. Ng is associated with cognitive decline in Alzheimer's disease and can be used as a synaptic biomarker for diagnosis. Cognitive dysfunction after stroke is associated with decrease of Ng expression in the brain. Ng is one of the sites of genetic variants associated with susceptibility to schizophrenia.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Rehabilitation Theory and Practice
Year:
2020
Document type:
Article