Profibrotic effect of mast cells on hyperoxia-induced lung injury / 国际儿科学杂志

ABSTRACT

Bronchopulmonary dysplasia(BPD)is a chronic lung disease that usually occurs in premature infants who require mechanical ventilation, with a high mortality rate, and there is currently a lack of effective prevention and treatment methods.The pathological features of typical BPD are mainly severe airway injury, lung parenchymal inflammation, squamous epithelial metaplasia, and pulmonary fibrosis.Although the pathogenesis of BPD is not yet clear, a large number of mast cell aggregation can be observed in the fibrotic lung of premature infants.Studies have suggested that a series of inflammatory mediators released by mast cell degranulation under hyperoxia have an important impact on BPD.This article reviews the role and mechanism of mast cells in promoting fibrosis in BPD, and in order to provide new ideas for the treatment of BPD.