Effects of OSAS on cardiac function and serum cystatin-C levels in patients with chronic heart failure / 中国医师杂志

ABSTRACT

Objective:To probe the influence of obstruction sleep apnea syndrome (OSAS) on cardiac function and serum cystatin-C (CC) levels in patients with chronic heart failure (CHF), and to discuss its clinical significance.Methods:129 CHF patients suspected of OSAS were selected and divided into observation group (with apnea) and control group (without apnea) according to sleep apnea hypopnea index (AHI). The observation group included mild, moderate and severe groups. After admission, the levels of left ventricular ejection fraction (LVEF), N-terminal forebrain natriuretic peptide (NT-proBNP) and CC were collected for further analysis.Results:The levels of NT-proBNP and CC in 99 patients with CHF complicated with OSAS were higher than those in the control group, while LVEF was lower than those in the control group ( P<0.05); The levels of NT-proBNP and CC in severe group were higher than those in mild and moderate group, while LVEF was significantly lower ( P<0.05); The level of CC in mild to moderate group was higher than that in control group, while LVEF was lower than that in control group ( P<0.05). Rank correlation analysis showed that CC was positively correlated with AHI ( r=0.726, P<0.01); However, there was no significant difference in NT proBNP between mild to moderate group and control group ( P>0.05). Conclusions:OSAS can lead to the deterioration of cardiac function. The CC of CHF patients with OSAS is higher and increases with the aggravation of obstruction. CC may participate in the progression of the disease. A high level of CC may aggravate the development of the disease, and the incidence and mortality of cardiovascular events may also increase.Early prevention and treatment should be given.