Research progress on ferroptosis and fatty liver ischemia-reperfusion injury / 中华肝胆外科杂志

ABSTRACT

Ferroptosis is a new type of cell death proposed in recent years. It refers to the excessive accumulation of reactive oxygen species under iron dependence, which leads to fatal lipid peroxidation of cells and ultimately leads to cell death. Fatty liver is extremely sensitive to ischemia-reperfusion injury and poorly tolerated. It’s still not understood well, and the therapeutic options are limited for the fatty liver patients. The pathophysiological characteristics of ferroptosis and fatty liver ischemia-reperfusion injury are similar, and the discovery of ferroptosis may provide a new treatment strategy for fatty liver to prevent ischemia-reperfusion injury. This article mainly reviews the mechanism of ferroptosis and the targets related to ferroptosis in fatty liver ischemia-reperfusion injury.