Incidence, risk factors and prognosis of acute kidney injury early after lung transplantation / 中华器官移植杂志

ABSTRACT

Objective:To explore the incidence, risk factors and outcome of acute kidney injury (AKI) early after lung transplantation (LT).Methods:Clinical data were retrospectively reviewed for 167 LT patients. AKI was defined according to the criteria of Kidney Disease Improving Global Outcomes (KDIGO) guideline within the first 7 days post-LT. AKI incidence was calculated. Multivariate analysis was performed to identify independent risk factors. Survival analysis was presented with the Kaplan-Meier curve.Results:The incidence of AKI early post-LT was 65.9%. Gender (male), preoperative higher serum creatinine (sCr), lower glomerular filtration rate (eGFR), extracorporeal membrane oxygenation (ECMO), mechanical ventilation (MV), intraoperative or postoperative hypotension, cardiovascular events, postoperative septic shock, multiple organ failure, ECMO support ≥2 days and reintubation were risk factors for AKI early post-LT ( P<0.05). Postoperative AKI was correlated with prolonged MV and/or ECMO as well as ICU stay and higher short/long-term mortality post-LT. Conclusions:The incidence of AKI early post-LT is high and affects the prognosis of LT patients. Greater attention should be paid to early prevention of AKI to reduce its incidence and improve its prognosis.