Clinical Characteristics of Acute Dichlorvos Poisoning in Korea
Journal of The Korean Society of Clinical Toxicology
; : 9-15, 2008.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-91541
Responsible library:
WPRO
ABSTRACT
Purpose:
Dichlorvos has been in widespread use as an organophosphate (OP) insecticide compound. The purpose of this study was to access the epidemiology and clinical features of dichlorvos in Korea.Methods:
This was a 38 multi-center prospective study of dichlorvos poisoning using surveys, a structural reporting system and review of hospital records from August 2005 to July 2006. A total of 54 patients with acute dichlorvos poisoning on a national basis were enrolled. We analyzed the epidemiologic characteristics and clinical manifestations of dichlorvos poisoning. In addition, the clinical features of dichlorvos poisoning were compared with others OP compounds.Results:
During the study period, compounds involving pure OP poisoning were dichlorvos (22.7%), methidathion (8.4%), and phosphamidon (6.7%). In acute dichlorvos poisoning, all ingestion routes were oral. Intentional poisoning involved 74.1% of cases. The common initial complaints involved gastrointestinal (64.8%), systemic (61.1%), central or peripheral nervous system (53.7%), and respiratory symptoms (50.0%). The median arrival time to hospital after dichlorvos poisoning was 2.6 hours and mean hospitalization duration was 7.1 days. 2-PAM was administered in 35 patients in mean doses of 6.3 g/day intravenously. Atropine was administered in 30 patients with a mean dose of 62.8 mg/day (maximal 240 mg/day). Overall mortality rate for dichlorvos poisonings were 14.8% (8/54). Immediate causes for death included sudden cardiac arrest or ventricular dysrhythmias (50%), multi-organ failure (25%), acute renal failure (12.5%), and unknown causes (12.5%).Conclusion:
When compared to previous reports, dichlorvos poisoning displayed relatively moderate severity. The presence of a lower GCS score, altered mental status, serious dysrhythmias, systemic shock, acute renal failure, and respiratory complications upon presentation were associated with a more serious and fatal poisoning.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Organothiophosphorus Compounds
/
Phosphamidon
/
Pralidoxime Compounds
/
Atropine
/
Shock
/
Hospital Records
/
Prospective Studies
/
Death, Sudden, Cardiac
/
Peripheral Nervous System
/
Dichlorvos
Type of study:
Controlled clinical trial
/
Observational study
Limits:
Humans
Country/Region as subject:
Asia
Language:
Korean
Journal:
Journal of The Korean Society of Clinical Toxicology
Year:
2008
Document type:
Article