Statin-Induced Immune-Mediated Necrotizing Myopathy with Anti-HMGCR Antibody / 대한신경근육질환학회지
Korean Journal of Neuromuscular Disorders
; (2): 64-66, 2021.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-917945
Responsible library:
WPRO
ABSTRACT
Anti-3-hydroxy-3-methylglutaryl coenzyme A reductase (anti-HMGCR) antibody related immune-mediated necrotizing myopathy (IMNM) are usually associated with statin use. The disease has features of persistent muscle weakness and creatine kinase (CK) elevation after statin discontinuation. This report describes a 65-year-old female taking atorvastatin, presenting with both proximal lower extremity weakness. IMNM feature were detected on muscle biopsy and high anti-HMGCR autoantibody titer on enzyme-linked immunosorbent assay (ELISA). This patient was treated with corticosteroid. Muscle weakness and CK are improved after immunosuppressive therapy.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Korean
Journal:
Korean Journal of Neuromuscular Disorders
Year:
2021
Document type:
Article