Chronic Exposure to Hypoxia Inhibits Myelinogenesis and Causes Motor Coordination Deficits in Adult Mice / 神经科学通报·英文版
Neuroscience Bulletin
; (6): 1397-1411, 2021.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-922649
Responsible library:
WPRO
ABSTRACT
Exposure to chronic hypoxia is considered to be a risk factor for deficits in brain function in adults, but the underlying mechanisms remain largely unknown. Since active myelinogenesis persists in the adult central nervous system, here we aimed to investigate the impact of chronic hypoxia on myelination and the related functional consequences in adult mice. Using a transgenic approach to label newly-generated myelin sheaths (NG2-CreER
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Mice, Transgenic
/
Oligodendroglia
/
Clemastine
/
Hypoxia
/
Mice, Inbred C57BL
/
Myelin Sheath
Type of study:
Etiology study
/
Risk factors
Limits:
Animals
Language:
English
Journal:
Neuroscience Bulletin
Year:
2021
Document type:
Article