The effect of a subhypnotic dose of propofol for the prevention of coughing in adults during emergence from anesthesia with sevoflurane and remifentanil / 대한마취과학회지
Korean Journal of Anesthesiology
; : 120-126, 2014.
Article
in En
| WPRIM
| ID: wpr-92343
Responsible library:
WPRO
ABSTRACT
BACKGROUND: Coughing during emergence from general anesthesia may be detrimental. Propofol is known to inhibit airway reflexes. We evaluated the incidence and severity of coughing in adults who received a subhypnotic dose of propofol at the end of sevoflurane-remifentanil anesthesia. METHODS: Sixty patients, aged 18-65 years, undergoing elective nasal surgery under general anesthesia using sevoflurane and remifentanil were randomly allocated to the propofol group (n = 30) or the control group (n = 30). At the end of surgery, sevoflurane and remifentanil infusion was stopped. After 3 min, the propofol group received propofol 0.3 mg/kg and the control group received normal saline 0.03 ml/kg. The incidence and severity of cough, recovery time and hemodynamic parameters were evaluated during the emergence period. RESULTS: During emergence, the propofol group had the significantly lower incidence (60 vs. 87%) and severity of coughing compared with the control group (P = 0.04, P = 0.02, respectively). There were no significant differences in mean arterial pressure, heart rate, and recovery time during emergence between the two groups. CONCLUSIONS: During emergence from sevoflurane-remifentanil anesthesia, a subhypnotic dose (0.3 mg/kg) of propofol decreases the incidence and severity of coughing without delaying wake up in adults undergoing nasal surgery.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Reflex
/
Propofol
/
Incidence
/
Cough
/
Nasal Surgical Procedures
/
Arterial Pressure
/
Heart Rate
/
Hemodynamics
/
Anesthesia
/
Anesthesia, General
Type of study:
Incidence_studies
/
Prognostic_studies
Limits:
Adult
/
Humans
Language:
En
Journal:
Korean Journal of Anesthesiology
Year:
2014
Document type:
Article