Research Progress of HO1 on AntiOxidative Stress Injury of MSC --Review / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 613-617, 2022.
Article
in Zh
| WPRIM
| ID: wpr-928762
Responsible library:
WPRO
ABSTRACT
Mesenchymal stem cell (MSC) is widely used in cell therapy because of its high proliferative and multi directional differentiation potential as well as its low immunogenicity. The transplantation of MSC can help the repair of the injured organs, however, the MSC transplanted to the local organs are affected by oxidative stress and lead to premature aging or apoptosis. Heme oxygenase 1 (HO1) is a key ratelimiting enzyme in the process of heme metabolism, which has the functions of antiinflammation, antioxidation, antiapoptosis, antiaging, reducing cell damage and promoting angiogenesis. Induced high expression of HO1 in MSC could increase the ability of MSC against oxidative stress injury, delay the senescence and apoptosis of MSC, and alleviate cell injury. In this reviews, the research progress of HO1 on antioxidative stress injury of MSC.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Cell Differentiation
/
Apoptosis
/
Oxidative Stress
/
Mesenchymal Stem Cell Transplantation
/
Heme Oxygenase-1
/
Mesenchymal Stem Cells
Limits:
Humans
Language:
Zh
Journal:
Journal of Experimental Hematology
Year:
2022
Document type:
Article