Polyhydroxylated eudesmane sesquiterpenoids and sesquiterpenoid glucoside from the flower buds of Tussilago farfara / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 301-308, 2022.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-929262
Responsible library:
WPRO
ABSTRACT
Chemical fractionation of the n-BuOH partition, which was generated from the EtOH extract of the flower buds of Tussilago farfara, afforded a series of polar constituents including four new sesquiterpenoids (1-4), one new sesquiterpenoid glucoside (5) and one known analogue (6) of the eudesmane type, as well as five known quinic acid derivatives (7-11). Structures of the new compounds were unambiguously characterized by detailed spectroscopic analyses, with their absolute configurations being established by X-ray crystallography, electronic circular dichroism (ECD) calculation and induced ECD experiments. The inhibitory effect of all the isolates against LPS-induced NO production in murine RAW264.7 macrophages was evaluated, with isochlorogenic acid A (7) showing significant inhibitory activity.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Sesquiterpenes
/
Tussilago
/
Flowers
/
Sesquiterpenes, Eudesmane
/
Glucosides
Limits:
Animals
Language:
English
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2022
Document type:
Article