Research progress in role of exosomes derived from mesenchymal stem cells in wound healing and regeneration / 中华创伤杂志

ABSTRACT

Exosomes derived from mesenchymal stem cells (MSCs) play a similar role of stem cells in promoting healing and regeneration of tissue and organ through paracrine, which avoids the risks of direct transplantation of mesenchymal stem cells such as tumorigenic, ethics, immune rejection, et al. Exosomes derived from MSCs that are able to participate in intercellular communication, maintain homeostasis of microenvironment, promote cell proliferation and migration, repair extracellular matrix, and transmit between different species without causing obvious immune response, exhibiting great potential in healing and regeneration of tissue and organ. The authors review the characteristics, extraction and identification of exosomes derived from MSCs and their application in the repair and regeneration of spinal cord, skin, bone, tendons, nerves and other tissues, hoping to provide a reference for clinical application of exosomes derived from MSCs in tissue and organ repair.