Cancer cells corrupt normal epithelial cells through miR-let-7c-rich small extracellular vesicle-mediated downregulation of p53/PTEN / 国际口腔科学杂志·英文版
International Journal of Oral Science
; (4): 36-36, 2022.
Article
in En
| WPRIM
| ID: wpr-939855
Responsible library:
WPRO
ABSTRACT
Tumor volume increases continuously in the advanced stage, and aside from the self-renewal of tumor cells, whether the oncogenic transformation of surrounding normal cells is involved in this process is currently unclear. Here, we show that oral squamous cell carcinoma (OSCC)-derived small extracellular vesicles (sEVs) promote the proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) of normal epithelial cells but delay their apoptosis. In addition, nuclear-cytoplasmic invaginations and multiple nucleoli are observed in sEV-treated normal cells, both of which are typical characteristics of premalignant lesions of OSCC. Mechanistically, miR-let-7c in OSCC-derived sEVs is transferred to normal epithelial cells, leading to the transcriptional inhibition of p53 and inactivation of the p53/PTEN pathway. In summary, we demonstrate that OSCC-derived sEVs promote the precancerous transformation of normal epithelial cells, in which the miR-let-7c/p53/PTEN pathway plays an important role. Our findings reveal that cancer cells can corrupt normal epithelial cells through sEVs, which provides new insight into the progression of OSCC.
Full text:
1
Database:
WPRIM
Main subject:
Mouth Neoplasms
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Carcinoma, Squamous Cell
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Down-Regulation
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Cell Movement
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Cell Transformation, Neoplastic
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Tumor Suppressor Protein p53
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MicroRNAs
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Cell Line, Tumor
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Cell Proliferation
/
Epithelial Cells
Limits:
Humans
Language:
En
Journal:
International Journal of Oral Science
Year:
2022
Document type:
Article