Clinical Analysis of 739 Cases of Midtrimester Amniocentesis / 대한주산의학회잡지
Korean Journal of Perinatology
; : 146-153, 2005.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-94225
Responsible library:
WPRO
ABSTRACT
OBJECTIVE:
To analyze the change of indications and chromosomal abnormalities according to patient's age and indications in midtrimester genetic amniocentesis.METHODS:
This study was reviewed 739 genetic amniocentesis results which were performed at Kwangju Christian Hospital from 1995 to 2004, as prenatal genetic diagnosis for the possibility of chromosomal abnormality of fetus. Age distribution, gestational weeks, indications of amniocentesis and cytogenetic results were the key factors for the analysis.RESULTS:
Maternal ages were ranged from 25 to 45, mostly 25~39, Of indications of prenatal genetic amniocentesis, abnormal maternal serum marker was the most common (49.8%), and followed by advanced maternal age (31.1%). The frequency of abnormal karyotypes was 4.6% (34/739). The incidence of abnormal karyotype according to indication had statistical significance in abnormal ultrasonographic finding.CONCLUSION:
Among the several indications for prenatal cytogenetic diagnosis, ultrasonographic abnormalities and abnormal maternal serum markers might be important indications. Especially, ultrasonographic abnormalities could be the predictive markers for abnormal fetal karyotypes.
Full text:
Available
Health context:
SDG3 - Health and Well-Being
/
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Target 3.1: Reduce maternal mortality
/
Congenital and Chromosomal Anomalies
Database:
WPRIM (Western Pacific)
Main subject:
Pregnancy Trimester, Second
/
Prenatal Diagnosis
/
Biomarkers
/
Incidence
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Chromosome Aberrations
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Maternal Age
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Age Distribution
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Cytogenetics
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Diagnosis
/
Fetus
Type of study:
Diagnostic study
/
Incidence study
/
Prognostic study
Limits:
Female
/
Humans
/
Pregnancy
Language:
Korean
Journal:
Korean Journal of Perinatology
Year:
2005
Document type:
Article