Effects of arteannuin B, arteannuic acid and scopoletin on pharmacokinetics of artemisinin in mice
Asian Pacific Journal of Tropical Medicine
; (12): 677-681, 2016.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-951372
Responsible library:
WPRO
ABSTRACT
Objective To explore the effects of arteannuin B, arteannuic acid and scopoletin on the pharmacokinetics of artemisinin in mice. Methods Artemisinin and a combination of artemisinin, arteannuin B, arteannuic acid and scopoletin were administered together to mice via oral administration. Blood samples were collected at different time intervals and pretreated by liquid–liquid extraction. The contents of four compounds in mouse plasma were determined by a validated HPLC-MS/MS method. Results Compared to single artemisinin group, the C
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Asian Pacific Journal of Tropical Medicine
Year:
2016
Document type:
Article