Antiprotozoal assessment and phenolic acid profiling of five Fumaria (fumitory) species
Asian Pacific Journal of Tropical Medicine
; (12): 283-286, 2015.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-951566
Responsible library:
WPRO
ABSTRACT
Objective:
To explore some Fumaria species which were recorded to be traditionally used against malaria and other protozoal diseases.Methods:
Consequently, in the current study, antiprotozoal effect of the ethanol extracts obtained from five Fumaria species (Fumaria densiflora, Fumaria cilicica, Fumaria rostellata, Fumaria kralikii, and Fumaria parviflora) was investigated against the parasites; Plasmodium falciparum (malaria) and Trypanosoma bruceirhodesiense (human African trypanosomiasis) at 0.81 and 4.85 μg/mL concentrations.Results:
Among them, Fumaria densiflora extract exerted the highest antiplasmodial (93.80%) and antitrypanasomal effect (55.40%), while the ethanol extracts of Fumaria kralikii (43.45%) and Fumaria rostellata (41.65%) showed moderate activity against Plasmodium falciparum. Besides, phenolic acid contents of the extracts were analyzed using high performance liquid chromatography (HPLC) and trans-cinnamic (4.32 mg/g) and caffeic (3.71 mg/g) acids were found to be the dominant phenolic acids in Fumaria densiflora.Conclusions:
According to our results, Fumaria densiflora deserve further study for its promising antiprotozoal activity.
Full text:
Available
Health context:
Neglected Diseases
Health problem:
Malaria
/
Trypanosomiasis
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Asian Pacific Journal of Tropical Medicine
Year:
2015
Document type:
Article