Your browser doesn't support javascript.
loading
Antiprotozoal assessment and phenolic acid profiling of five Fumaria (fumitory) species
Article in Chinese | WPRIM (Western Pacific) | ID: wpr-951566
Responsible library: WPRO
ABSTRACT

Objective:

To explore some Fumaria species which were recorded to be traditionally used against malaria and other protozoal diseases.

Methods:

Consequently, in the current study, antiprotozoal effect of the ethanol extracts obtained from five Fumaria species (Fumaria densiflora, Fumaria cilicica, Fumaria rostellata, Fumaria kralikii, and Fumaria parviflora) was investigated against the parasites; Plasmodium falciparum (malaria) and Trypanosoma bruceirhodesiense (human African trypanosomiasis) at 0.81 and 4.85 μg/mL concentrations.

Results:

Among them, Fumaria densiflora extract exerted the highest antiplasmodial (93.80%) and antitrypanasomal effect (55.40%), while the ethanol extracts of Fumaria kralikii (43.45%) and Fumaria rostellata (41.65%) showed moderate activity against Plasmodium falciparum. Besides, phenolic acid contents of the extracts were analyzed using high performance liquid chromatography (HPLC) and trans-cinnamic (4.32 mg/g) and caffeic (3.71 mg/g) acids were found to be the dominant phenolic acids in Fumaria densiflora.

Conclusions:

According to our results, Fumaria densiflora deserve further study for its promising antiprotozoal activity.

Full text: Available Health context: Neglected Diseases Health problem: Malaria / Trypanosomiasis Database: WPRIM (Western Pacific) Language: Chinese Journal: Asian Pacific Journal of Tropical Medicine Year: 2015 Document type: Article
Full text: Available Health context: Neglected Diseases Health problem: Malaria / Trypanosomiasis Database: WPRIM (Western Pacific) Language: Chinese Journal: Asian Pacific Journal of Tropical Medicine Year: 2015 Document type: Article
...