Functional and binding studies of gallic acid showing platelet aggregation inhibitory effect as a thrombin inhibitor / 中草药·英文版
Chinese Herbal Medicines
; (4): 303-309, 2022.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-953589
Responsible library:
WPRO
ABSTRACT
Objective:
This study was devoted to identifying natural thrombin inhibitors from traditional Chinese medicine (TCM) and evaluating its biological activity in vitro and binding characteristics.Methods:
A combination strategy containing molecular docking, thrombin inhibition assay, surface plasmon resonance (SPR) and molecular dynamics simulation were applied to verify the study result.Results:
Gallic acid was confirmed as a direct thrombin inhibitor with IC
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Herbal Medicines
Year:
2022
Document type:
Article