AMP-activated protein kinase signaling pathway: a potential therapeutic target for ischemic stroke / 国际脑血管病杂志
International Journal of Cerebrovascular Diseases
; (12): 448-454, 2022.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-954154
Responsible library:
WPRO
ABSTRACT
AMP-activated protein kinase (AMPK) is an energy sensor, which can regulate the energy metabolism of cells by regulating mitochondrial oxidation capacity and substrate utilization, affecting various pathways such as glucose and fatty acid transport. Recent studies have shown that energy metabolism disturbance is a "blasting fuse" leading to a series of secondary injuries after cerebral ischemia-reperfusion, including oxidative stress, acidosis, apoptosis, and excitotoxicity. AMPK participates in most pathophysiological processes of cerebral ischemia-reperfusion injury by regulating cellular energy metabolism. This article reviews the mechanism of action of AMPK signaling pathway in cerebral ischemia-reperfusion injury.
Full text:
Available
Database:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
International Journal of Cerebrovascular Diseases
Year:
2022
Document type:
Article